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Il-1R–Associated kinase 4 deficiency

MeSH: C564352ORPHA: 70592

Contents

  1. 1. Overview
  2. 2. Available Treatments
  3. 3. Clinical Presentation
  4. 4. Classification & Codes

Overview

Interleukin-1 receptor-associated kinase-4 (IRAK-4) deficiency is an immunodeficiency associated with increased susceptibility to invasive infections caused by pyogenic bacteria

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Il-1R–Associated kinase 4 deficiency, sourced from HPO and Orphanet clinical annotations.

Decreased total neutrophil countRecurrent bacterial infectionsImmunodeficiencyRecurrent streptococcus pneumoniae infectionsRecurrent staphylococcal infectionsRecurrent bacterial skin infectionsFever

Classification & Codes

MeSH Code

C564352

Orphanet Code

ORPHA:70592
Il-1R–Associated kinase 4 deficiency
MeSHC564352
OrphanetORPHA:70592
Treatments0 drug(s)
Symptoms on record7 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO