immunodeficiency due to selective anti-polysaccharide antibody deficiency
ORPHA: 70593
Overview
Immunodeficiency due to selective anti-polysaccharide antibody deficiency is characterized by normal immunoglobulin levels (including IgG sub-classes) but impaired polysaccharide responsiveness (IPR)
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with immunodeficiency due to selective anti-polysaccharide antibody deficiency, sourced from HPO and Orphanet clinical annotations.
Decreased specific anti-polysaccharide antibody levelDecreased specific antibody response to polysaccharide vaccineComplete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccineDecreased specific antibody response to protein-conjugated polysaccharide vaccineComplete or near-complete absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccineSinusitisOtitis mediaRhinitisDecreased proportion of memory B cellsRecurrent bacterial upper respiratory tract infectionsRecurrent upper and lower respiratory tract infectionsAtopic dermatitisAsthmaRecurrent bacterial meningitisDecreased total B cell count
Classification & Codes
Orphanet Code
ORPHA:70593immunodeficiency due to selective anti-polysaccharide antibody deficiency
| Orphanet | ORPHA:70593 |
| Treatments | 0 drug(s) |
| Symptoms on record | 15 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO