infantile-onset ascending hereditary spastic paralysis
ICD-10: G12.2MeSH: C537217ORPHA: 1216
Overview
Infantile-onset ascending hereditary spastic paralysis (IAHSP) is a very rare motor neuron disease characterized by severe spasticity of the lower limbs in early life, progression of spasticity to the upper limbs in late childhood, and dysarthria
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with infantile-onset ascending hereditary spastic paralysis, sourced from HPO and Orphanet clinical annotations.
HypotoniaJoint stiffnessDistal amyotrophyCachexiaNonprogressive muscular atrophy
Classification & Codes
ICD-10 Code
G12.2MeSH Code
C537217Orphanet Code
ORPHA:1216infantile-onset ascending hereditary spastic paralysis
| ICD-10 | G12.2 |
| MeSH | C537217 |
| Orphanet | ORPHA:1216 |
| Treatments | 0 drug(s) |
| Symptoms on record | 5 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO