intrahepatic cholestasis of pregnancy
MeSH: C535932ORPHA: 69665
Overview
intrahepatic cholestasis characterized by reversible cholestasis typically occurring in the second or third trimester of pregnancy, elevated serum aminotransferases and bile acid level and resolution of symptoms by 2 to 3 weeks after delivery
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with intrahepatic cholestasis of pregnancy, sourced from HPO and Orphanet clinical annotations.
HypothyroidismJaundiceCholecystitisTremorSmall for gestational ageAscitesPremature birthAbnormality of the pancreasAbdominal painAsterixisPruritusIncreased serum bile acid concentrationElevated circulating hepatic transaminase concentrationAbnormality of the digestive systemInsomniaDepressionNeonatal respiratory distressHyperbilirubinemiaElevated circulating alkaline phosphatase concentrationAbnormal circulating interleukin concentrationMeconium stained amniotic fluidAbnormal pineal melatonin secretionPruritus on footPalmar pruritus
Classification & Codes
MeSH Code
C535932Orphanet Code
ORPHA:69665intrahepatic cholestasis of pregnancy
| MeSH | C535932 |
| Orphanet | ORPHA:69665 |
| Treatments | 0 drug(s) |
| Symptoms on record | 24 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO