Job's syndrome
MeSH: D007589ORPHA: 2314
Overview
autosomal dominant form called Job's syndrome or Buckley syndrome, is a heterogeneous group of immune disorders
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Job's syndrome, sourced from HPO and Orphanet clinical annotations.
Eczematoid dermatitisSkin rashPruritusRecurrent respiratory infectionsRecurrent infectionsIncreased circulating IgE concentrationGeneralized abnormality of skinAtelectasisSkin ulcerAbnormality of the dentitionCleft palateGingivitisAbnormality of the faceMandibular prognathiaFacial asymmetryChronic otitis mediaWide nasal bridgeDeeply set eyeDelayed eruption of teethDentinogenesis imperfectaOsteopeniaOsteoporosisXanthelasmaAbnormal hair morphologyParonychiaIncreased total eosinophil countGastroesophageal refluxBronchiectasisScoliosisRecurrent Staphylococcus aureus infectionsChronic mucocutaneous candidiasisRecurrent fracturesRecurrent pneumoniaDystrophic fingernailsProminent foreheadCoughPulmonary pneumatoceleCutaneous abscessOpportunistic infectionPapuleCraniosynostosisFeverVascular dilatationLymphomaOsteomyelitisChiari type I malformationCellulitisSkin vesicleJoint hypermobility
Classification & Codes
MeSH Code
D007589Orphanet Code
ORPHA:2314Job's syndrome
| MeSH | D007589 |
| Orphanet | ORPHA:2314 |
| Treatments | 0 drug(s) |
| Symptoms on record | 49 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO