Jokela type spinal muscular atrophy

ORPHA: 276435

Overview

neuromuscular disease

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Jokela type spinal muscular atrophy, sourced from HPO and Orphanet clinical annotations.

Distal lower limb muscle weaknessHyporeflexiaAreflexiaGait disturbanceFasciculationsElevated circulating creatine kinase concentrationEMG: neuropathic changesCold-induced muscle crampsExercise-induced muscle crampsIncreased intramuscular fatProximal lower limb muscle weaknessGastrocnemius myalgiaTongue fasciculationsTremorDysphagiaRagged-red muscle fibersEMG: myopathic abnormalitiesRimmed vacuolesImpaired distal vibration sensationIntrinsic hand muscle atrophyProximal upper limb muscle weaknessAbnormal sensory nerve conduction velocityAbnormality of the respiratory systemBulbar signsInability to walk

Classification & Codes

Orphanet Code

ORPHA:276435
Jokela type spinal muscular atrophy
OrphanetORPHA:276435
Treatments0 drug(s)
Symptoms on record25 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO