LADD syndrome
ICD-10: Q87.8MeSH: C538132ORPHA: 589905
Overview
autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with LADD syndrome, sourced from HPO and Orphanet clinical annotations.
MacrotiaIntellectual disabilityNeurodevelopmental delayThin vermilion borderHypertelorismLong philtrumHigh foreheadBroad nasal tipAnteverted naresAbnormality of refractionHypermetropiaSynophrysCafe-au-lait spotTapered fingerHypotoniaClinodactyly of the 5th fingerIncreased body weightAttention deficit hyperactivity disorderFeeding difficulties in infancyFatigueImpulsivityCryptorchidismEpicanthusRecurrent otitis mediaStrabismusPtosisUpslanted palpebral fissureSeizureGait disturbanceNeonatal hypotoniaConstipationGastroesophageal refluxSleep disturbanceHand tremorGeneralized joint hypermobilityRecurrent upper respiratory tract infections2-3 toe syndactylyAlmond-shaped palpebral fissureObesityBlindnessKidney failureHematuriaConduct disorderGlomerulonephritisBody dysmorphic disorderDisability affecting intellectual abilitiesShort statureHearing loss
Classification & Codes
ICD-10 Code
Q87.8MeSH Code
C538132Orphanet Code
ORPHA:589905LADD syndrome
| ICD-10 | Q87.8 |
| MeSH | C538132 |
| Orphanet | ORPHA:589905 |
| Treatments | 0 drug(s) |
| Symptoms on record | 48 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO