Lambert-Eaton myasthenic syndrome
MeSH: D015624ORPHA: 43393
Overview
an autoimmune, presynaptic disorder of neuromuscular transmission characterized by fluctuating muscle weakness and autonomic dysfunction frequently associated with small-cell lung cancer (SCLC)
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Lambert-Eaton myasthenic syndrome, sourced from HPO and Orphanet clinical annotations.
XerostomiaReduced tendon reflexesEMG: decremental response of compound muscle action potential to repetitive nerve stimulationProgressive proximal muscle weaknessAbnormal autonomic nervous system physiologyEMG: repetitive nerve stimulation abnormalityCalcium channel antibody positivityAbnormality of the orbital regionImpotenceConstipationBulbar signsSmall cell lung carcinomaAnti-P/Q-type VGCC antibody positivityHypohidrosisKeratoconjunctivitis siccaOrthostatic hypotension due to autonomic dysfunction
Classification & Codes
MeSH Code
D015624Orphanet Code
ORPHA:43393Lambert-Eaton myasthenic syndrome
| MeSH | D015624 |
| Orphanet | ORPHA:43393 |
| Treatments | 0 drug(s) |
| Symptoms on record | 16 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO