Landau–Kleffner syndrome
ICD-10: F80.3MeSH: D018887ORPHA: 98818
Overview
a rare childhood neurological syndrome characterized by seizures and progressive loss of speech typically in a child with previous age-appropriate development
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Landau–Kleffner syndrome, sourced from HPO and Orphanet clinical annotations.
SeizureLoss of speechAphasiaLanguage impairmentSpeech apraxiaInterictal EEG abnormalitySpoken word recognition deficitContinuous spike and waves during slow sleepAtypical behaviorAutistic behaviorGeneralized non-motor (absence) seizureDevelopmental regressionAttention deficit hyperactivity disorderSocial and occupational deteriorationSpeech articulation difficultiesFocal motor seizureEEG with generalized epileptiform dischargesEEG with frontal focal spikesEEG with temporal focal spikesBilateral tonic-clonic seizure with generalized onsetEmotional labilityDepressionAggressive behaviorShort attention spanAnxietyHyperactivitySlurred speechGait ataxiaBilateral tonic-clonic seizureMutismMemory impairmentFrequent fallsSleep disturbanceFocal impaired awareness seizureSteppage gaitDifficulty standingAtypical absence seizureFocal myoclonic seizureGeneralized clonic seizureNocturnal seizuresNon-convulsive status epilepticus without comaImpulsivityAutoimmune antibody positivityEpileptic encephalopathy
Classification & Codes
ICD-10 Code
F80.3MeSH Code
D018887Orphanet Code
ORPHA:98818Landau–Kleffner syndrome
| ICD-10 | F80.3 |
| MeSH | D018887 |
| Orphanet | ORPHA:98818 |
| Treatments | 0 drug(s) |
| Symptoms on record | 44 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO