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Langerhans-cell histiocytosis

ICD-10: C96.6MeSH: D006646ORPHA: 389

Contents

  1. 1. Overview
  2. 2. Available Treatments
  3. 3. Clinical Presentation
  4. 4. Classification & Codes

Overview

disease involving clonal proliferation of Langerhans cells

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Langerhans-cell histiocytosis, sourced from HPO and Orphanet clinical annotations.

Bone painOsteolysisEczematoid dermatitisSkin rashSplenomegalyFeverHepatomegalyLymphadenopathyCoughOral ulcerHearing impairmentDiabetes insipidusAtaxiaDysarthriaMental deteriorationGrowth delayWeight lossThrombocytopeniaDecreased total leukocyte countSpontaneous pneumothoraxHypoalbuminemiaGenital ulcersReduced circulating growth hormone concentrationPulmonary Langerhans cell histiocytosisHepatic failureRespiratory insufficiencySclerosing cholangitis

Classification & Codes

ICD-10 Code

C96.6

MeSH Code

D006646

Orphanet Code

ORPHA:389
Langerhans-cell histiocytosis
ICD-10C96.6
MeSHD006646
OrphanetORPHA:389
Treatments0 drug(s)
Symptoms on record27 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO