Laron syndrome
MeSH: D046150ORPHA: 633
Overview
congenital disorder characterized by marked short stature associated with normal or high serum growth hormone (GH) and low serum insulin-like growth factor-1 (IGF-I) levels which fail to rise after exogenous GH administration
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Laron syndrome, sourced from HPO and Orphanet clinical annotations.
MicrognathiaHigh foreheadDepressed nasal ridgeBlue scleraeDelayed eruption of teethMicrodontiaAbnormality of the endocrine systemDelayed pubertyAbnormal skull morphologyHypohidrosisBrachydactylyIntellectual disabilityMotor delayAbnormally high-pitched voiceShort toeHypoglycemiaTruncal obesityAbnormal facial shapeDelayed skeletal maturationOsteoarthritisHypercholesterolemiaSevere short statureHypoplastic nasal bridgePrematurely aged appearanceHypoplasia of penisTooth agenesisAbnormality of the elbowUnderdeveloped supraorbital ridgesAplasia/Hypoplasia involving the nose
Classification & Codes
MeSH Code
D046150Orphanet Code
ORPHA:633Laron syndrome
| MeSH | D046150 |
| Orphanet | ORPHA:633 |
| Treatments | 0 drug(s) |
| Symptoms on record | 29 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO