lateral sclerosis
ORPHA: 35689
Overview
motor neuron disease characterized by painless but progressive weakness and stiffness of the muscles of the legs
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with lateral sclerosis, sourced from HPO and Orphanet clinical annotations.
Upper motor neuron dysfunctionBabinski signGeneralized hyperreflexiaUrinary urgencyDysphagiaSpastic gaitGait imbalancePseudobulbar signsIncoordinationLoss of speechSpasticityAbnormal upper motor neuron morphologySpastic dysarthriaEMG: chronic denervation signsProgressive spastic paraparesisImpaired smooth pursuitWeakness due to upper motor neuron dysfunctionHoffmann signHypernasal speechAtrophy of the spinal cordMotor axonal neuropathyCervical spinal cord atrophyCognitive impairment
Classification & Codes
Orphanet Code
ORPHA:35689lateral sclerosis
| Orphanet | ORPHA:35689 |
| Treatments | 0 drug(s) |
| Symptoms on record | 23 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO