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Lelis syndrome

MeSH: C564261ORPHA: 140936

Contents

  1. 1. Overview
  2. 2. Available Treatments
  3. 3. Clinical Presentation
  4. 4. Classification & Codes

Overview

Lelis syndrome is characterised by the association of ectodermal dysplasia (hypotrichosis and hypohidrosis) with acanthosis nigricans

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Lelis syndrome, sourced from HPO and Orphanet clinical annotations.

Acanthosis nigricansHypohidrosisSparse hairAbnormality of the mouthFurrowed tongueHypodontiaPalmoplantar hyperkeratosisIntellectual disabilityNail dystrophyPerioral hyperpigmentationLong faceMandibular prognathiaExotropiaUpslanted palpebral fissureCarious teethVitiligoAbnormally high-pitched voiceSparse lateral eyebrowAbsent lower eyelashesAbnormal toenail morphologyYellow nailsMidface retrusion

Classification & Codes

MeSH Code

C564261

Orphanet Code

ORPHA:140936
Lelis syndrome
MeSHC564261
OrphanetORPHA:140936
Treatments0 drug(s)
Symptoms on record22 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO