LIPE-related familial partial lipodystrophy

ORPHA: 435660

Overview

human disease

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with LIPE-related familial partial lipodystrophy, sourced from HPO and Orphanet clinical annotations.

Increased adipose tissue around the neckInsulin resistanceLoss of subcutaneous adipose tissue in limbsLipodystrophyPolycystic ovariesInsulin-resistant diabetes mellitusOligomenorrheaAcanthosis nigricansHepatic steatosisHypertriglyceridemiaHepatomegalyElevated circulating creatine kinase concentrationDecreased serum leptinSkeletal muscle hypertrophyIncreased intraabdominal fatLoss of gluteal subcutaneous adipose tissueAbnormal labia majora morphologyDecreased adiponectin levelProximal lower limb muscle weaknessProximal upper limb muscle weakness

Classification & Codes

Orphanet Code

ORPHA:435660
LIPE-related familial partial lipodystrophy
OrphanetORPHA:435660
Treatments0 drug(s)
Symptoms on record20 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO
LIPE-related familial partial lipodystrophy | OrphanDrug