lipoatrophic diabetes
MeSH: D003923ORPHA: 528
Overview
type 2 diabetes that involves severe lipodystrophy in addition to the traditional signs of diabetes
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with lipoatrophic diabetes, sourced from HPO and Orphanet clinical annotations.
Insulin resistanceHepatomegalySkeletal muscle hypertrophyAdipose tissue lossLipodystrophyDiabetes mellitusHypertrichosisIntellectual disabilityHypertriglyceridemiaMacroglossiaLow anterior hairlineMandibular prognathiaProminent supraorbital ridgesHyperinsulinemiaAcanthosis nigricansProminent superficial veinsLarge handsGlobal developmental delayCirrhosisHepatic steatosisFailure to thriveCongestive heart failureHypertrophic cardiomyopathyLong footAbnormal facial shapeLow posterior hairlineHypercholesterolemiaOvergrowth of external genitaliaAccelerated skeletal maturationClitoral hypertrophyProportionate tall statureBone cystIncreased C-peptide levelAmenorrheaPolycystic ovariesOligomenorrheaPrecocious puberty in females
Classification & Codes
MeSH Code
D003923Orphanet Code
ORPHA:528lipoatrophic diabetes
| MeSH | D003923 |
| Orphanet | ORPHA:528 |
| Treatments | 0 drug(s) |
| Symptoms on record | 37 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO