locked-in syndrome
MeSH: D000080422ORPHA: 2406
Overview
condition in which a patient is aware but cannot move or communicate verbally due to complete paralysis of nearly all voluntary muscles in the body except for vertical eye movements and blinking
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with locked-in syndrome, sourced from HPO and Orphanet clinical annotations.
Hearing impairmentAbnormality of the eyeAbnormality of visionDiplopiaAtypical behaviorSpasticityHypertoniaAbnormality of the voiceRespiratory insufficiencyRecurrent respiratory infectionsTetraparesisAnarthriaTetraplegiaExcessive salivationFeeding difficultiesCerebral palsy
Classification & Codes
MeSH Code
D000080422Orphanet Code
ORPHA:2406locked-in syndrome
| MeSH | D000080422 |
| Orphanet | ORPHA:2406 |
| Treatments | 0 drug(s) |
| Symptoms on record | 16 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO