macrophage activation syndrome

MeSH: D055501ORPHA: 158061

Overview

complication of several chronic rheumatic diseases of childhood

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with macrophage activation syndrome, sourced from HPO and Orphanet clinical annotations.

Decreased liver functionThrombocytopeniaAnemiaFeverAutoimmunityHypoalbuminemiaIncreased circulating ferritin concentrationElevated erythrocyte sedimentation rateAbnormal circulating interleukin concentrationAbnormality of tumor necrosis factor secretionHemophagocytosisIncreased inflammatory responseIncreased circulating lactate dehydrogenase concentrationIncreased circulating interferon-gamma concentrationIncreased circulating interleukin 6 concentrationElevated circulating alanine aminotransferase concentrationAbnormal total natural killer cell countSplenomegalyDecreased total neutrophil countHypertriglyceridemiaLymphadenopathyJuvenile rheumatoid arthritisElevated circulating C-reactive protein concentrationHypofibrinogenemiaElevated circulating aspartate aminotransferase concentrationEncephalopathyHepatomegalySystemic lupus erythematosusHepatitis

Classification & Codes

MeSH Code

D055501

Orphanet Code

ORPHA:158061
macrophage activation syndrome
MeSHD055501
OrphanetORPHA:158061
Treatments0 drug(s)
Symptoms on record29 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO
macrophage activation syndrome | OrphanDrug