Maffucci syndrome

ORPHA: 163634

Overview

syndrome characterized by the presence of multiple enchondromas (benign growths of cartilage) associated with multiple cavernous hemangiomas and phleboliths

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Maffucci syndrome, sourced from HPO and Orphanet clinical annotations.

GoiterSubcutaneous noduleGrowth delayDysphagiaScoliosisBone painRecurrent fracturesOsteolysisPituitary adenomaParathyroid adenomaBreast carcinomaShort statureVenous thrombosisMultiple enchondromatosisChondrosarcomaCranial nerve paralysisHemangiomatosisAstrocytomaCerebral palsySarcomaOvarian neoplasmNeoplasm of the adrenal cortexNeoplasm of the parathyroid glandExostoses

Classification & Codes

Orphanet Code

ORPHA:163634
Maffucci syndrome
OrphanetORPHA:163634
Treatments0 drug(s)
Symptoms on record24 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO
Maffucci syndrome | OrphanDrug