malignant hyperthermia
MeSH: D008305ORPHA: 423
Overview
genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with malignant hyperthermia, sourced from HPO and Orphanet clinical annotations.
Metabolic acidosisFeverMalignant hyperthermiaTachypneaHyperphosphatemiaMuscle stiffnessSupraventricular tachycardiaVentricular tachycardiaIntermittent painful muscle spasmsHypercapniaCardiomyocyte mitochondrial proliferationHigh-output congestive heart failureAcute kidney injuryHyperkalemiaMyoglobinuriaAbnormality of the coagulation cascadeAcute hepatic failurePremature ventricular contractionElevated creatine kinase after exerciseAcute rhabdomyolysisNecrotizing myopathyExercise-induced rhabdomyolysisAbnormality of masseter muscle
Classification & Codes
MeSH Code
D008305Orphanet Code
ORPHA:423malignant hyperthermia
| MeSH | D008305 |
| Orphanet | ORPHA:423 |
| Treatments | 0 drug(s) |
| Symptoms on record | 23 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO