maturity-onset diabetes of the young

ORPHA: 552

Overview

genetic disease that has material basis in mutations in the MODY genes disrupting insulin production

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with maturity-onset diabetes of the young, sourced from HPO and Orphanet clinical annotations.

Glucose intoleranceHyperglycemiaGlycosuriaAbnormal oral glucose toleranceAbnormal circulating C-peptide concentrationAbnormal circulating insulin concentrationHypoinsulinemiaElevated hemoglobin A1cNephropathyRetinopathyHyperinsulinemic hypoglycemiaInsulin-resistant diabetes mellitusIntrauterine growth retardationLarge for gestational ageNeonatal hypoglycemiaTransient neonatal diabetes mellitusOverweightAbnormality of the kidneyRenal cystAbnormality of the genitourinary systemObesityExocrine pancreatic insufficiencyPancreatic hypoplasiaHepatocellular adenoma

Classification & Codes

Orphanet Code

ORPHA:552
maturity-onset diabetes of the young
OrphanetORPHA:552
Treatments0 drug(s)
Symptoms on record24 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO