Melnick–Needles syndrome
ORPHA: 2484
Overview
congenital disorder that affects primarily bone development.
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Melnick–Needles syndrome, sourced from HPO and Orphanet clinical annotations.
Joint hypermobilityDelayed cranial suture closureHypertelorismProminent supraorbital ridgesMicrognathiaProptosisNarrow chestAbnormal metaphysis morphologyAbnormal cortical bone morphologyShort statureBowing of the long bonesShort thoraxVesicoureteral refluxHydronephrosisFull cheeksFacial asymmetryHearing impairmentDelayed eruption of teethTooth malpositionAbnormal rib morphologyShort claviclesAbnormal cardiac septum morphologyFrontal bossingRecurrent respiratory infectionsScoliosisCoxa valgaHip dislocationAnisospondylyAbnormal pubic bone morphologyCraniofacial hyperostosisOsteolytic defects of the phalanges of the handShort distal phalanx of fingerCone-shaped epiphyses of the phalanges of the handOmphaloceleRespiratory insufficiency
Classification & Codes
Orphanet Code
ORPHA:2484Melnick–Needles syndrome
| Orphanet | ORPHA:2484 |
| Treatments | 0 drug(s) |
| Symptoms on record | 35 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO