melorheostosis
ICD-10: M85.8MeSH: D008557ORPHA: 2485
Overview
osteosclerosis that has material basis in a mutation of the LEMD3 gene which results in a hyperdense bony cortex
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with melorheostosis, sourced from HPO and Orphanet clinical annotations.
Abnormality of the skeletal systemLymphedemaJoint stiffnessFailure to thriveSkeletal dysplasiaBone painArthralgiaSkeletal muscle atrophyCranial nerve paralysisIncreased bone mineral densityEctopic ossification in muscle tissueHyperostosisLower limb asymmetryUpper limb asymmetryAtypical scarring of skinArthritisPeripheral arteriovenous fistula
Classification & Codes
ICD-10 Code
M85.8MeSH Code
D008557Orphanet Code
ORPHA:2485melorheostosis
| ICD-10 | M85.8 |
| MeSH | D008557 |
| Orphanet | ORPHA:2485 |
| Treatments | 0 drug(s) |
| Symptoms on record | 17 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO