multicentric osteolysis-nodulosis-arthropathy spectrum
ORPHA: 371428
Available Treatments (0)
No treatments linked yet
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Clinical Presentation
Signs and symptoms associated with multicentric osteolysis-nodulosis-arthropathy spectrum, sourced from HPO and Orphanet clinical annotations.
OsteopeniaOsteoporosisHirsutismArthritisCarpal osteolysisAbnormal facial shapeOsteolysisArthropathyAbnormal hand morphologyOsteolysis involving tarsal bonesOsteolysis involving bones of the lower limbsOsteolysis involving bones of the upper limbsBrachycephalyBroad claviclesBroad metacarpalsSubcutaneous noduleAbnormality of the cardiovascular systemAbnormal form of the vertebral bodiesSclerotic cranial suturesLocalized skin lesionPolycystic ovariesAbnormality of the orbital regionIris colobomaHypertensionPterygiumPapilledemaIntellectual disabilityOmphaloceleVentricular septal defectAtrial septal defectMitral valve prolapseBicuspid aortic valveAtrioventricular blockCoarctation of aortaDouble outlet right ventricleIncreased susceptibility to fracturesNodular goiterPremature thelarcheType I diabetes mellitus
Classification & Codes
Orphanet Code
ORPHA:371428multicentric osteolysis-nodulosis-arthropathy spectrum
| Orphanet | ORPHA:371428 |
| Treatments | 0 drug(s) |
| Symptoms on record | 39 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO