multiple endocrine neoplasia type 1
MeSH: D018761ORPHA: 652
Overview
autosomal dominant disease that has material basis in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with multiple endocrine neoplasia type 1, sourced from HPO and Orphanet clinical annotations.
HypercalcemiaPrimary hyperparathyroidismParathyroid hyperplasiaAngiofibromasImpairment of activities of daily livingImpotenceAdrenocortical abnormalityMultiple lipomasWeight lossDiarrheaGastroesophageal refluxAbdominal painZollinger-Ellison syndromeHypercalciuriaPituitary adenomaNeoplasm of the pancreasReduced bone mineral densityPeptic ulcerLarge cafe-au-lait macules with irregular marginsPituitary prolactin cell adenomaDecreased male libidoGalactorrheaHypergastrinemiaAmenorrheaGingival fibromatosisDepressionShort attention spanNephrolithiasisHypertensionElevated circulating growth hormone concentrationGoiterLethargyConfusionCranial nerve compressionPrimary hypercortisolismDehydrationVomitingNauseaConstipationAnorexiaHematemesisMelenaHeadacheDuodenal ulcerIncreased susceptibility to fracturesOsteolysisMeningiomaThyroid carcinomaIncreased circulating cortisol levelIntestinal carcinoidAdrenocortical carcinomaConfetti-like hypopigmented maculesProportionate tall staturePituitary growth hormone cell adenomaInsulinomaShortened QT intervalPancreatic endocrine tumorDecreased vigilanceAbnormal circulating aldosterone concentrationCarcinoid tumorComaPheochromocytomaEpendymomaIncreased serum serotoninElevated circulating calcitonin concentrationParathyroid carcinomaPituitary corticotropic cell adenomaAtypical absence status epilepticusPituitary gonadotropic cell adenomaPituitary null cell adenomaPituitary thyrotropic cell adenomaGlucagonomaPulmonary carcinoid tumorThymoma
Classification & Codes
MeSH Code
D018761Orphanet Code
ORPHA:652multiple endocrine neoplasia type 1
| MeSH | D018761 |
| Orphanet | ORPHA:652 |
| Treatments | 0 drug(s) |
| Symptoms on record | 74 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO