myelofibrosis
MeSH: D055728ORPHA: 824
Overview
myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with myelofibrosis, sourced from HPO and Orphanet clinical annotations.
Abnormal bone marrow cell morphologyPallorHepatosplenomegalySplenomegalyAbnormality of blood and blood-forming tissuesThrombocytopeniaAnemiaHepatomegalyAbnormal megakaryocyte morphologyFatigueConstitutional symptomPetechiaePurpuraPortal hypertensionPancytopeniaAbnormal bleedingThrombocytosisFeverIncreased total leukocyte countAbnormal thrombosisExtramedullary hematopoiesisAnorexiaLymphadenopathyEasy fatigabilityArterial thrombosisPoikilocytosisVenous thrombosisLow-grade feverFlank painBone marrow hypercellularityEcchymosisHemangiomaCachexiaHematological neoplasmIncreased circulating lactate dehydrogenase concentration
Classification & Codes
MeSH Code
D055728Orphanet Code
ORPHA:824myelofibrosis
| MeSH | D055728 |
| Orphanet | ORPHA:824 |
| Treatments | 0 drug(s) |
| Symptoms on record | 35 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO