neuroleptic malignant syndrome
ICD-10: G21.0MeSH: D009459ORPHA: 94093
Overview
nervous system disease that is characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness and is associated with administration of antipsychotic and other central dopaminergic blockers
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with neuroleptic malignant syndrome, sourced from HPO and Orphanet clinical annotations.
HyperhidrosisFeverMutismReduced consciousnessExtrapyramidal muscular rigidityAbnormal autonomic nervous system physiologyHypertensionTremorTachycardiaMetabolic acidosisIncreased total leukocyte countDysphagiaDroolingElevated circulating creatine kinase concentrationMuscle spasmExcessive salivationFatigueUrinary incontinenceProteinuriaAgitationAnxietyComaEncephalopathyThrombocytosisAcute kidney injuryDehydrationVomitingNauseaChoreaHyperuricemiaHyperkalemiaPulmonary embolismHypotensionHypocalcemiaHyponatremiaHyperphosphatemiaElevated circulating hepatic transaminase concentrationMyoglobinuriaHypomagnesemiaElevated circulating alkaline phosphatase concentrationRhabdomyolysisHypernatremiaOculogyric crisisArrhythmiaAspiration pneumoniaRigorsIncreased circulating lactate dehydrogenase concentrationDeliriumNasogastric tube feedingHypertensive crisisBradycardiaThrombocytopeniaHypothermiaSepsis
Classification & Codes
ICD-10 Code
G21.0MeSH Code
D009459Orphanet Code
ORPHA:94093neuroleptic malignant syndrome
| ICD-10 | G21.0 |
| MeSH | D009459 |
| Orphanet | ORPHA:94093 |
| Treatments | 0 drug(s) |
| Symptoms on record | 54 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO