obesity due to pro-opiomelanocortin deficiency
MeSH: C565726ORPHA: 71526
Overview
Pro-opiomelanocortin (POMC) deficiency is a form of monogenic obesity resulting in severe early-onset obesity, adrenal insufficiency, red hair and pale skin
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with obesity due to pro-opiomelanocortin deficiency, sourced from HPO and Orphanet clinical annotations.
ObesityIncreased adipose tissuePolyphagiaHypopigmentation of the skinCholestasisRed hairChildhood-onset truncal obesityCentral adrenal insufficiencyDelayed pubertyDecreased response to growth hormone stimulation testHyperinsulinemiaAcanthosis nigricansFailure to thriveGrowth delayHypoglycemic seizuresDelayed skeletal maturationGonadotropin deficiencyPituitary hypothyroidism
Classification & Codes
MeSH Code
C565726Orphanet Code
ORPHA:71526obesity due to pro-opiomelanocortin deficiency
| MeSH | C565726 |
| Orphanet | ORPHA:71526 |
| Treatments | 0 drug(s) |
| Symptoms on record | 18 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO