overlap myositis

ORPHA: 206572

Overview

Overlap myositis (OM) is a form of idiopathic inflammatory myopathy (IIM) characterized by myositis with at least one clinical and/or autoantibody overlap feature

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with overlap myositis, sourced from HPO and Orphanet clinical annotations.

HypertensionArthritisDysphagiaAutoimmunityAbnormal circulating lipid concentrationElevated circulating creatine kinase concentrationAntinuclear antibody positivityProximal muscle weaknessProximal upper limb muscle weaknessSclerodactylyFinger swellingConstitutional symptomAnti-topoisomerase I antibody positivityRaynaud phenomenonSevere infectionAnti-Sm antibody positivityAnti-Ro/SS-A antibody positivityAnti-PM-Scl antibody positivityAnti-Ku antibody positivityAnti-Ro52/TRIM21 antibody positivityPerifascicular muscle fiber atrophyAbnormality of the kidneyDiabetes mellitusGait disturbanceAbnormal heart morphologyThrombocytopeniaDecreased total leukocyte countPulmonary arterial hypertensionTetraparesisSystemic lupus erythematosusElevated circulating hepatic transaminase concentrationAbnormality of connective tissueDifficulty climbing stairsSubluxation of the small joints of the handAbnormal pulmonary interstitial morphologyDistal lower limb muscle weaknessLimb painAbnormal skin morphologySclerodermaRheumatoid arthritis

Classification & Codes

Orphanet Code

ORPHA:206572
overlap myositis
OrphanetORPHA:206572
Treatments0 drug(s)
Symptoms on record40 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO