Papillon-Lefevre disease
MeSH: D010214ORPHA: 678
Overview
Human disease
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Papillon-Lefevre disease, sourced from HPO and Orphanet clinical annotations.
Abnormality of the dentitionSevere periodontitisGingivitisPeriodontitisPalmoplantar hyperkeratosisPalmoplantar keratodermaHypertrichosisHypopigmented skin patchesCigarette-paper scarsArachnodactylyAbnormal fingernail morphologyRecurrent skin infectionsAbnormal nail morphologyRecurrent respiratory infectionsGeneralized hirsutismSparse body hairCerebral calcificationOsteolysisSquamous cell carcinomaMelanomaAtrophy of alveolar ridgesPremature loss of primary teethNeoplasm of the skinNail dystrophyTooth agenesisChronic furunculosisLiver abscessRecurrent cutaneous abscess formationPustule
Classification & Codes
MeSH Code
D010214Orphanet Code
ORPHA:678Papillon-Lefevre disease
| MeSH | D010214 |
| Orphanet | ORPHA:678 |
| Treatments | 0 drug(s) |
| Symptoms on record | 29 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO