paroxysmal nocturnal hemoglobinuria
MeSH: D006457ORPHA: 447
Overview
disease of the blood characterized by destruction of red blood cells by the complement system, a part of the body's innate immune system
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with paroxysmal nocturnal hemoglobinuria, sourced from HPO and Orphanet clinical annotations.
Abnormal erythrocyte enzyme concentration or activityHemolytic anemiaAnemiaHemoglobinuriaAstheniaThromboembolismReticulocytosisDyspneaHeadacheEpisodic abdominal painDeep venous thrombosisIncreased blood urea nitrogenVenous thrombosisUnconjugated hyperbilirubinemiaHemosiderinuriaChronic kidney diseaseReduced haptoglobin levelIncreased circulating lactate dehydrogenase concentrationConjunctival icterusErythromelalgiaDecreased circulating iron concentrationChest painRenal insufficiencyProteinuriaImpotenceHypertensionJaundiceLethargyStrokeMyocardial infarctionThrombocytopeniaPancytopeniaDecreased total leukocyte countAcute kidney injuryPulmonary embolismBudd-Chiari syndromeArterial thrombosisErythroid hyperplasiaMesenteric venous thrombosisOdynophagiaRenal Fanconi syndromeDysphagiaGlycosuriaEsophageal spasms
Classification & Codes
MeSH Code
D006457Orphanet Code
ORPHA:447paroxysmal nocturnal hemoglobinuria
| MeSH | D006457 |
| Orphanet | ORPHA:447 |
| Treatments | 0 drug(s) |
| Symptoms on record | 44 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO