polymyositis
ICD-10: M33.2MeSH: D017285ORPHA: 732
Overview
rare idiopathic inflammatory myopathy characterized by symmetric proximal muscle weakness and elevated muscle enzymes
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with polymyositis, sourced from HPO and Orphanet clinical annotations.
HypotoniaArthralgiaAutoimmunityElevated circulating creatine kinase concentrationEMG abnormalityProximal muscle weaknessAbnormal muscle fiber morphologyElevated circulating aldolase concentrationCoughArthritisWeight lossFeverConstipationAnorexiaRespiratory insufficiencyExertional dyspneaMyalgiaAntinuclear antibody positivityAbnormal pulmonary interstitial morphologyFatigueAnti-signal recognition particle antibody positivityAnti-threonyl-tRNA synthetase antibody positivityAnti-alanyl-tRNA synthetase antibody positivityAnti-glycyl tRNA-synthetase antibody positivityAnti-aminoacyl-tRNA synthetase antibody positivityAnti-isoleucyl tRNA-synthetase antibody positivityAnti-phenylalanyl tRNA synthetase antibody positivityAnti-tyrosyl-tRNA synthetase antibody positivityAnti-asparaginyl-tRNA synthetase antibody positivityAnti-histidyl tRNA synthetase antibody positivityAbnormal renal tubule morphologyChondrocalcinosisSkin rashGait disturbanceReduced tendon reflexesAbnormality of the voiceHypernasal speechDysphoniaAbnormal mitral valve morphologyCongestive heart failureHypertrophic cardiomyopathyDilated cardiomyopathyMyocardial infarctionPericarditisThrombocytosisGastroesophageal refluxAbdominal painNeuromuscular dysphagiaPulmonary fibrosisGastrointestinal hemorrhageHepatomegalyVasculitisElevated erythrocyte sedimentation rateVenous thrombosisAbnormal atrioventricular conductionArrhythmiaRaynaud phenomenonChest tightnessCamptocormiaIncreased total lymphocyte countMyocarditisMuscle weakness
Classification & Codes
ICD-10 Code
M33.2MeSH Code
D017285Orphanet Code
ORPHA:732polymyositis
| ICD-10 | M33.2 |
| MeSH | D017285 |
| Orphanet | ORPHA:732 |
| Treatments | 0 drug(s) |
| Symptoms on record | 62 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO