primary coenzyme Q10 deficiency 4

ORPHA: 139485

Overview

primary coenzyme Q10 deficiency that has material basis in an autosomal recessive mutation of ADCK3 on chromosome 1q42.13

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with primary coenzyme Q10 deficiency 4, sourced from HPO and Orphanet clinical annotations.

Cerebellar atrophyProgressive cerebellar ataxiaHypotoniaBrisk reflexesModerate intellectual disabilityDevelopmental regressionExercise intoleranceProximal muscle weaknessTalipes cavus equinovarusFocal T2 hypointense basal ganglia lesionStrabismusSeizureMyoclonusTremorHyperreflexiaIncreased circulating lactate concentrationIncreased CSF lactateLactic acidosisEMG abnormalityAbnormal pyramidal signNeurodevelopmental delayHearing impairmentGynecomastiaDystonia

Classification & Codes

Orphanet Code

ORPHA:139485
primary coenzyme Q10 deficiency 4
OrphanetORPHA:139485
Treatments0 drug(s)
Symptoms on record24 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO