progressive supranuclear palsy
MeSH: D013494ORPHA: 683
Overview
neurodegenerative disease characterized by supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with progressive supranuclear palsy, sourced from HPO and Orphanet clinical annotations.
Supranuclear gaze palsySupranuclear ophthalmoplegiaDysphagiaPostural instabilityUnsteady gaitFallsNeuronal loss in central nervous systemAbnormal synaptic transmissionImpulsivityVisual impairmentVertical supranuclear gaze palsySlow saccadic eye movementsBlepharospasmEmotional labilityDepressionIrritabilityApathyDelayed speech and language developmentDysarthriaDystoniaBradykinesiaCerebral cortical atrophyGliosisPseudobulbar signsVertigoMemory impairmentAphasiaCognitive impairmentAbnormality of eye movementDementiaTremorRigidity
Classification & Codes
MeSH Code
D013494Orphanet Code
ORPHA:683progressive supranuclear palsy
| MeSH | D013494 |
| Orphanet | ORPHA:683 |
| Treatments | 0 drug(s) |
| Symptoms on record | 32 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO