progressive supranuclear palsy-corticobasal syndrome
ORPHA: 240103
Overview
PSP-corticobasal syndrome (PSP-CBS) is an atypical variant of progressive supranuclear palsy (PSP; see this term), a rare late-onset neurodegenerative disease
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with progressive supranuclear palsy-corticobasal syndrome, sourced from HPO and Orphanet clinical annotations.
ApraxiaSomatic sensory dysfunctionProgressive extrapyramidal muscular rigidityBradykinesiaSlow saccadic eye movementsPostural instabilityRigidityFrequent fallsRespiratory distressDysphagiaDiminished movementDysarthriaMemory impairmentVertical supranuclear gaze palsyAphasiaSpeech articulation difficultiesFocal dystoniaTremorAbnormal pyramidal signLimb apraxiaLimb myoclonusInvoluntary movementsSlowed horizontal saccadesJerky head movementsHand clenchingAbnormal saccadic eye movementsMental deteriorationPersonality changesParkinsonism with favorable response to dopaminergic medication
Classification & Codes
Orphanet Code
ORPHA:240103progressive supranuclear palsy-corticobasal syndrome
| Orphanet | ORPHA:240103 |
| Treatments | 0 drug(s) |
| Symptoms on record | 29 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO