progressive supranuclear palsy-pure akinesia with gait freezing syndrome
ORPHA: 240094
Overview
PSP-Pure akinesia with gait freezing (PSP-PAGF) is an atypical variant of progressive supranuclear palsy (PSP; see this term), a rare late-onset neurodegenerative disease
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with progressive supranuclear palsy-pure akinesia with gait freezing syndrome, sourced from HPO and Orphanet clinical annotations.
AkinesiaFreezing of gaitUnsteady gaitWeak voiceGait imbalanceSpastic dysarthriaFixed facial expressionAbnormal prosodyPalilaliaMicrographiaTachylaliaDementiaLoss of ambulationFallsShort stepped shuffling gaitDistal lower limb muscle weaknessHypometric saccadesBlepharospasmOculomotor apraxia
Classification & Codes
Orphanet Code
ORPHA:240094progressive supranuclear palsy-pure akinesia with gait freezing syndrome
| Orphanet | ORPHA:240094 |
| Treatments | 0 drug(s) |
| Symptoms on record | 19 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO