Raine syndrome
MeSH: C535282ORPHA: 1832
Overview
Lethal osteosclerotic bone dysplasia is defined by generalized osteosclerosis with periosteal bone formation, characteristic facial dysmorphism, brain abnormalities including intracerebral calcifications, and neonatal lethal course
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Raine syndrome, sourced from HPO and Orphanet clinical annotations.
Large fontanellesMicrocephalyDelayed cranial suture closureRetrognathiaMicrognathiaPosteriorly rotated earsLow-set earsDepressed nasal ridgeAnteverted naresShort neckGingival fibromatosisGingival overgrowthProptosisIntrauterine growth retardationDyspneaRespiratory distressRespiratory failureShort noseMandibular aplasiaMedian cleft palate
Classification & Codes
MeSH Code
C535282Orphanet Code
ORPHA:1832Raine syndrome
| MeSH | C535282 |
| Orphanet | ORPHA:1832 |
| Treatments | 0 drug(s) |
| Symptoms on record | 20 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO