Reynolds syndrome
ORPHA: 779
Overview
Reynolds syndrome (RS) is an autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc) (see these terms)
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Reynolds syndrome, sourced from HPO and Orphanet clinical annotations.
XerostomiaJaundiceSkin rashPruritusKeratoconjunctivitis siccaArthritisCirrhosisAscitesFeverDysphagiaGastroesophageal refluxRespiratory insufficiencyHepatomegalyInfectious encephalitisMyalgiaAbnormal gastric mucosa morphologyIrregular hyperpigmentationGeneralized abnormality of skinSclerodactylyFatigueMucosal telangiectasiaeTelangiectasia of the skinLichenificationSkin ulcer
Classification & Codes
Orphanet Code
ORPHA:779Reynolds syndrome
| Orphanet | ORPHA:779 |
| Treatments | 0 drug(s) |
| Symptoms on record | 24 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO