sclerosteosis
MeSH: C537525ORPHA: 3152
Overview
hyperostosis characterized by excessive bone formation most prominent in the skull, mandible, clavicle, ribs and diaphyses of long bones; bone formation occurs throughout life
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with sclerosteosis, sourced from HPO and Orphanet clinical annotations.
Tall statureAbnormality of the noseSensorineural hearing impairmentPtosisOptic atrophy2-3 finger cutaneous syndactylyAbnormal cortical bone morphologyCraniofacial hyperostosisDiaphyseal undertubulationFinger syndactylyCurved distal phalanges of the handFacial palsyIncreased bone mineral densityFingernail dysplasia
Classification & Codes
MeSH Code
C537525Orphanet Code
ORPHA:3152sclerosteosis
| MeSH | C537525 |
| Orphanet | ORPHA:3152 |
| Treatments | 0 drug(s) |
| Symptoms on record | 14 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO