selective IgM deficiency disease

ICD-10: D80.4ORPHA: 331235

Contents

1. Overview
2. Available Treatments
3. Clinical Presentation
4. Classification & Codes

Overview

selective immunoglobulin deficiency disease thatis a dysgammaglobulinemia resulting from decreased levels of immunoglobulin M (IgM) production to roduction of other antibodies

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with selective IgM deficiency disease, sourced from HPO and Orphanet clinical annotations.

Recurrent infectionsSevere infectionAtopic dermatitisGrowth delayVerrucaeRaynaud phenomenonDecreased circulating total IgMRecurrent respiratory infectionsChronic fatigueKeratitisChronic sinusitisRecurrent urinary tract infectionsBronchiectasisNontuberculous mycobacterial pulmonary infectionPulmonary tuberculosisAutoimmunityHashimoto thyroiditisSystemic lupus erythematosusRheumatoid arthritisAutoimmune thrombocytopeniaAutoimmune neutropeniaAntinuclear antibody positivityRecurrent vulvovaginal candidiasisCellulitisLymphadenitisRecurrent herpesOtitis mediaPharyngitisSevere viral infectionTooth abscessNon-infectious meningitisRecurrent cutaneous fungal infectionsRecurrent staphylococcal infectionsFasciitisRecurrent bronchitisCutaneous abscessRecurrent shinglesOnychomycosisChronic oral candidiasisChronic diarrheaSevere varicella zoster infectionAllergyAllergic rhinitisAsthmaParaproteinemiaMultiple myelomaNon-Hodgkin lymphomaThyroid carcinomaStomach cancerDecreased total T cell countDecreased CD4+ T cell proportionDecreased CD8+ T cell proportionDecreased transitional B cell proportionDecreased specific antibody response to vaccinationCrohn's diseaseRecurrent upper respiratory tract infectionsRecurrent pneumoniaRecurrent sinusitisLymphadenopathyRecurrent infection of the gastrointestinal tractMeningitisSepsis

Classification & Codes

ICD-10 Code

D80.4

Orphanet Code

ORPHA:331235

selective IgM deficiency disease

ICD-10	`D80.4`
Orphanet	`ORPHA:331235`
Treatments	0 drug(s)
Symptoms on record	62 signs
Status	published

Factual Authority

Last Updated3/20/2026

Clinical DataHPO · Orphanet

Drug DataFDA · EMA · CDSCO