Shapiro syndrome
MeSH: C537594ORPHA: 29822
Overview
Spontaneous periodic hypothermia (SPH) is a neurological disorder characterized by spontaneous periodic hypothermia and hyperhidrosis in the absence of hypothalamic lesions
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Shapiro syndrome, sourced from HPO and Orphanet clinical annotations.
HyperhidrosisPallorSkin rashSeizureAtaxiaGait disturbanceTremorDiarrheaNausea and vomitingHypothermiaSleep disturbanceAbnormal pattern of respirationReduced consciousnessAplasia/Hypoplasia of the corpus callosumArrhythmiaFatigue
Classification & Codes
MeSH Code
C537594Orphanet Code
ORPHA:29822Shapiro syndrome
| MeSH | C537594 |
| Orphanet | ORPHA:29822 |
| Treatments | 0 drug(s) |
| Symptoms on record | 16 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO