silver-Russell syndrome due to an imprinting defect of 11p15
ORPHA: 2311402 Treatments Available
Overview
human disease
Available Treatments (2)
| Drug | Form | Status | Countries | Lead Time |
|---|---|---|---|---|
| mecasermin Orphan Cold Chain | subcutaneous injection, 10 mg/mL solution | FDA Approved, EMA Approved | 8 | 14d |
| Growth Hormone Cold Chain | Subcutaneous injection, 5mg, 12mg cartridges | FDA Approved | 11 | 10d |
Clinical Presentation
Signs and symptoms associated with silver-Russell syndrome due to an imprinting defect of 11p15, sourced from HPO and Orphanet clinical annotations.
Triangular faceShort chinSmall for gestational ageDelayed skeletal maturationShort statureAsymmetric growthHigh palateProtruding earDental crowdingClinodactyly of the 5th fingerDecreased body weightRelative macrocephalyFeeding difficulties in infancyPostnatal growth retardationProminent foreheadLower limb asymmetryUpper limb asymmetryAbnormal external genitalia morphologyNevus flammeusIntellectual disabilitySeizureMotor delayDiastasis rectiHypoglycemiaNeonatal hypoglycemiaPolydactylyHyperhidrosisDelayed closure of the anterior fontanelle
Classification & Codes
Orphanet Code
ORPHA:231140silver-Russell syndrome due to an imprinting defect of 11p15
| Orphanet | ORPHA:231140 |
| Treatments | 2 drug(s) |
| Symptoms on record | 28 signs |
| Status | published |
Treatment Summary
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO