simple cryoglobulinemia
ORPHA: 91139
Overview
Simple (monoclonal) cryoglobulinemia or type I cryoglobulinemia refers to the presence in the serum of one isotype or subclass of immunoglobulin (Ig) that precipitates reversibly below 37°C
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with simple cryoglobulinemia, sourced from HPO and Orphanet clinical annotations.
Chronic lymphatic leukemiaViral hepatitisCranial nerve paralysisAbnormality of the gastrointestinal tractMonoclonal elevation of circulating IgAPurpuraAbnormality of blood and blood-forming tissuesCold urticariaUnexplained feversIncreased circulating IgM levelAcral ulcerationDistal peripheral sensory neuropathySensorimotor neuropathyPeripheral neuropathyLocalized skin lesionFatigueRaynaud phenomenonParaproteinemiaMultiple mononeuropathyLivedo racemosaAbnormality of the kidneyRenal insufficiencyProteinuriaMembranoproliferative glomerulonephritisHypertensionArthritisWeight lossVasculitisArthralgiaMicroscopic hematuriaParesthesiaMonoclonal immunoglobulin M proteinemiaMultiple myelomaSpontaneous pain sensationVascular skin abnormalityB-cell lymphomaMesangial hypercellularityMonoclonal elevation of IgGNephrotic syndromeNephritisSeizureStrokeAbnormal heart morphologyCongestive heart failureMyocardial infarctionPericarditisMorphological central nervous system abnormalityAbdominal painAbnormal lung morphologyGastrointestinal hemorrhageHeadacheProgressive neurologic deteriorationRheumatoid factor positiveFunctional motor deficitReduced circulating complement concentration
Classification & Codes
Orphanet Code
ORPHA:91139simple cryoglobulinemia
| Orphanet | ORPHA:91139 |
| Treatments | 0 drug(s) |
| Symptoms on record | 55 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO