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spastic paraplegia-Paget disease of bone syndrome

ORPHA: 329475

Contents

  1. 1. Available Treatments
  2. 2. Clinical Presentation
  3. 3. Classification & Codes

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with spastic paraplegia-Paget disease of bone syndrome, sourced from HPO and Orphanet clinical annotations.

Spastic paraplegiaGait disturbanceSpastic gaitLower limb hyperreflexiaElevated circulating alkaline phosphatase concentrationGeneralized muscle weaknessEMG: neuropathic changesBabinski signBone painRecurrent fracturesArthralgiaIncreased spinal bone densityAbnormal skeletal morphologyTongue fasciculationsLimb fasciculations

Classification & Codes

Orphanet Code

ORPHA:329475
spastic paraplegia-Paget disease of bone syndrome
OrphanetORPHA:329475
Treatments0 drug(s)
Symptoms on record15 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO