spinocerebellar ataxia type 25
MeSH: C537202ORPHA: 101111
Overview
Spinocerebellar ataxia type 25 (SCA25) is a very rare subtype of type I autosomal dominant cerebellar ataxia (ADCA type I; see this term). It is characterized by cerebellar ataxia and prominent sensory neuropathy.
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with spinocerebellar ataxia type 25, sourced from HPO and Orphanet clinical annotations.
Impaired pain sensationReduced visual acuityFacial ticsAbnormal cerebellar cortex morphologyDiffuse cerebellar atrophyFacial myokymiaVomitingEpisodic abdominal painProgressive cerebellar ataxiaUrinary urgencyStrabismusNystagmusSensory neuropathyPes cavusGait ataxiaSpastic dysarthriaAreflexia of lower limbsScoliosisDistal sensory impairmentDecreased number of large peripheral myelinated nerve fibersEMG: neuropathic changesBabinski signImpaired distal tactile sensation
Classification & Codes
MeSH Code
C537202Orphanet Code
ORPHA:101111spinocerebellar ataxia type 25
| MeSH | C537202 |
| Orphanet | ORPHA:101111 |
| Treatments | 0 drug(s) |
| Symptoms on record | 23 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO