spinocerebellar ataxia type 28
MeSH: C537205ORPHA: 101109
Overview
Spinocerebellar ataxia type 28 (SCA28) is a very rare subtype of type I autosomal dominant cerebellar ataxia (ADCA type I; see this term). It is characterized by juvenile onset, slowly progressive cerebellar ataxia due to Purkinje cell degeneration.
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with spinocerebellar ataxia type 28, sourced from HPO and Orphanet clinical annotations.
DysarthriaGait ataxiaLimb ataxiaLower limb hyperreflexiaPtosisSlow saccadic eye movementsOphthalmoparesisNystagmusBabinski signParkinsonismKinetic tremorAtypical behaviorDepressionSpasticityDystoniaRigidityHead tremorMemory impairmentLimb dystoniaCognitive impairment
Classification & Codes
MeSH Code
C537205Orphanet Code
ORPHA:101109spinocerebellar ataxia type 28
| MeSH | C537205 |
| Orphanet | ORPHA:101109 |
| Treatments | 0 drug(s) |
| Symptoms on record | 20 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO