sporadic Creutzfeldt-Jakob disease

ORPHA: 204

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with sporadic Creutzfeldt-Jakob disease, sourced from HPO and Orphanet clinical annotations.

HeadacheVertigoSleep disturbanceLoss of speechUpper motor neuron dysfunctionBabinski signHyperactive deep tendon reflexesAbnormal pyramidal signFatigueDementiaNeuronal loss in central nervous systemCerebral cortex with spongiform changesAkinetic mutismHyperintensity of cerebral white matter on MRIAtypical behaviorAtaxiaConfusionMyoclonusCerebral atrophyRecurrent aspiration pneumoniaGliosisMemory impairmentVisual hallucinationAstrocytosisHypsarrhythmiaRecurrent infectionsIncreased CSF protein concentrationRespiratory failure requiring assisted ventilationCognitive impairmentSepsisVisual impairmentEmotional labilityDepressionIrritabilityApathySpasticityAbnormality of extrapyramidal motor function

Classification & Codes

Orphanet Code

ORPHA:204
sporadic Creutzfeldt-Jakob disease
OrphanetORPHA:204
Treatments0 drug(s)
Symptoms on record37 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO