Stiff Person Syndrome
ICD-10: G25.82MeSH: D016750ORPHA: 3198
Overview
Stiff person syndrome is a rare autoimmune neurological disorder characterized by progressive muscle rigidity, painful spasms, and heightened sensitivity to stimuli. Most cases are associated with anti-glutamic acid decarboxylase (anti-GAD) antibodies, though anti-amphiphysin and anti-glycine receptor antibodies are found in paraneoplastic variants. The estimated prevalence is approximately 1-2 per million, with a 2:1 female predominance.
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Stiff Person Syndrome, sourced from HPO and Orphanet clinical annotations.
AnxietyHyperhidrosisFallsEMG abnormalityIntermittent painful muscle spasmsEmotional labilityAgoraphobiaGait disturbanceMyoclonusHyperreflexiaDysphagiaConstipationRigidityExaggerated startle responseMyalgiaParaspinal muscle hypertrophyAutoimmune antibody positivityCognitive impairmentAnti-Amphiphysin antibodyAnti-DPPX antibodyAnti-GAD65 antibodyAnti-Gephyrin antibodyAnti-GlyR antibodyDiplopiaDiabetes mellitusHypothyroidismApneaVertigoLumbar hyperlordosisFreezing of gait
Classification & Codes
ICD-10 Code
G25.82MeSH Code
D016750Orphanet Code
ORPHA:3198Stiff Person Syndrome
| ICD-10 | G25.82 |
| MeSH | D016750 |
| Orphanet | ORPHA:3198 |
| Treatments | 0 drug(s) |
| Symptoms on record | 30 signs |
| Status | published |
Factual Authority
Last Updated3/21/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO