stiff-person syndrome
MeSH: D016750ORPHA: 3198
Overview
rare neurologic disorder characterized by progressive rigidity and stiffness in truncal muscles, spasms, postural deformities, chronic pain, impaired mobility, and lumbar hyperlordosis
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with stiff-person syndrome, sourced from HPO and Orphanet clinical annotations.
AnxietyHyperhidrosisFallsEMG abnormalityIntermittent painful muscle spasmsEmotional labilityAgoraphobiaGait disturbanceMyoclonusHyperreflexiaDysphagiaConstipationRigidityExaggerated startle responseMyalgiaParaspinal muscle hypertrophyAutoimmune antibody positivityCognitive impairmentAnti-Amphiphysin antibodyAnti-DPPX antibodyAnti-GAD65 antibodyAnti-Gephyrin antibodyAnti-GlyR antibodyDiplopiaDiabetes mellitusHypothyroidismApneaVertigoLumbar hyperlordosisFreezing of gait
Classification & Codes
MeSH Code
D016750Orphanet Code
ORPHA:3198stiff-person syndrome
| MeSH | D016750 |
| Orphanet | ORPHA:3198 |
| Treatments | 0 drug(s) |
| Symptoms on record | 30 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO