T-cell immunodeficiency, congenital alopecia, and nail dystrophy

MeSH: C536781ORPHA: 169095

Contents

1. Overview
2. Available Treatments
3. Clinical Presentation
4. Classification & Codes

Overview

severe combined immunodeficiency characterized by congenital alopecia, severe T-cell immunodeficiency, and ridging, pitting or curving of all nails that has material basis in homozygous mutation in the FOXN1 gene on chromosome 17q11-q12

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with T-cell immunodeficiency, congenital alopecia, and nail dystrophy, sourced from HPO and Orphanet clinical annotations.

Nail pitsRidged nailImmunodeficiencyDecreased total T cell countCongenital alopecia totalis

Classification & Codes

MeSH Code

C536781

Orphanet Code

ORPHA:169095

T-cell immunodeficiency, congenital alopecia, and nail dystrophy

MeSH	`C536781`
Orphanet	`ORPHA:169095`
Treatments	0 drug(s)
Symptoms on record	5 signs
Status	published

Factual Authority

Last Updated3/20/2026

Clinical DataHPO · Orphanet

Drug DataFDA · EMA · CDSCO