TSH-secreting pituitary adenoma
ORPHA: 91347
Overview
rare adenoma of the anterior lobe of the pituitary gland that produces thyrotropin. It is usually associated with goiter and hyperthyroidism
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with TSH-secreting pituitary adenoma, sourced from HPO and Orphanet clinical annotations.
HyperthyroidismGoiterElevated circulating thyroid-stimulating hormone concentrationAbnormal pituitary gland morphologyEnlarged pituitary glandMale hypogonadismHypogonadotropic hypogonadismFemale hypogonadismHypogonadismAbnormality of the menstrual cycleProgressive visual lossGynecomastiaImpotenceIrregular menstruationDecreased fertility in femalesOsteopeniaOsteoporosisHyperhidrosisPallorTremorWeight lossPalpitationsVomitingNausea and vomitingHeadacheHypotensionDecreased circulating ACTH concentrationEasy fatigabilitySecondary growth hormone deficiencyAbnormal hair quantityCentral adrenal insufficiencyAdrenocorticotropin deficient adrenal insufficiencyAdrenocorticotropic hormone deficiencyThyroid crisisDecreased fertility in malesFatigueDecreased female libidoErectile dysfunctionPtosisBlindnessDiplopiaInfertilityHypertensionDelayed pubertyIncreased circulating gonadotropin levelElevated circulating growth hormone concentrationIncreased circulating prolactin concentrationSudden loss of visual acuitySeizureCongestive heart failurePericardial effusionVertigoHypokalemiaVentricular arrhythmiaSupraventricular arrhythmiaCranial nerve paralysisAbducens palsyFourth cranial nerve palsyInternal ophthalmoplegiaPeriodic hypokalemic paresisEuthyroid hyperthyroxinemiaOculomotor nerve palsyHemianopiaHeteronymous hemianopiaBitemporal hemianopiaAbnormal visual field test
Classification & Codes
Orphanet Code
ORPHA:91347TSH-secreting pituitary adenoma
| Orphanet | ORPHA:91347 |
| Treatments | 0 drug(s) |
| Symptoms on record | 66 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO