tuberous sclerosis

MeSH: D014402ORPHA: 805

Overview

rare multisystem genetic disease that causes benign tumors to grow in the brain and on other vital organs

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with tuberous sclerosis, sourced from HPO and Orphanet clinical annotations.

Abnormality of the kidneyAtypical behaviorSeizureCortical dysplasiaSubependymal nodulesCortical tubersHypomelanotic maculeGeneralized abnormality of skinRenal cystDepressionAutismAggressive behaviorAutistic behaviorHyperactivityIntellectual disabilitySpecific learning disabilityStatus epilepticusSleep disturbanceFocal-onset seizureConfetti-like hypopigmented maculesRepetitive compulsive behaviorRetinal hamartomaShagreen patchCardiac rhabdomyomaAngiofibromasEpileptic spasmAbnormal social behaviorInfantile spasmsChronic kidney diseaseNeurodevelopmental delayPulmonary lymphangiomyomatosisChorioretinal hypopigmentationImpulsivitySelf-injurious behaviorSkin plaqueRenal insufficiencyAnxietyHypertensionHepatic cystsRespiratory distressHemoptysisPoor speechRenal angiomyolipomaAttention deficit hyperactivity disorderSubependymal giant-cell astrocytomaNoncommunicating hydrocephalusRespiratory tract infectionUngual fibromaEpidermoid cystPolycystic kidney dysplasiaPheochromocytomaRespiratory failurePituitary adenomaParathyroid adenomaStage 5 chronic kidney diseaseAortic aneurysmRenal cell carcinomaParathyroid hyperplasiaInternal hemorrhageRetinal astrocytic hamartomaPancreatic endocrine tumorCarcinoid tumor

Classification & Codes

MeSH Code

D014402

Orphanet Code

ORPHA:805
tuberous sclerosis
MeSHD014402
OrphanetORPHA:805
Treatments0 drug(s)
Symptoms on record62 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO